Cannabidiol (CBD) use is widespread today, but over 60% of the population does not understand how CBD work to maintain Homeostasis. CBD is a Phytocannabinoid and works just like the cannabinoids found in the human endocannabinoid system. The distribution of cannabinoid receptors and endocannabinoid in the Endocannabinoid system (ECS) regulates various biological processes in our body. The ECS regulates Stress, mood, pain, anxiety, depression, appetite, and sleep. When there is hormonal imbalance, the body must work the extra mile to restore balance by activating the ECS. What is the Endocannabinoid System? Well, we covered everything you need to two about the human endocannabinoid system.
What is the Endocannabinoid System?
The endocannabinoid system (ECS) is a composition of cannabinoid receptors and endocannabinoids found in our bodies. All animals existing on this earth rely on their endocannabinoid system for well-being, which is crucial. The cannabinoid receptors are located on the cell surface, and their main task is to listen to body changes. By transmitting the changes on the body, the ECS takes necessary measures to restore balance. The primary cannabinoid receptors discovered by scientists are CB1 and CB2, and they play distinct roles.
CB1 receptors are majorly concentrated in the central nervous system and the brain. On the other hand, CB2 receptors are abundant in the tissues, organs, and immune system. another essential component of the endocannabinoid system is the endocannabinoids. Endocannabinoids are the cannabinoids produced by the body, while phytocannabinoid are those produced by plants like cannabis. Cannabinoids bind with the cannabinoid receptors to restore Homeostasis. The endocannabinoid has fat-like substances for easy breakdown after they have served their role.
Scientists discovered Anandamide and 2-Arachidonoylglycerol (2-AG) as the main Endocannabinoids. The other component of ECS is the metabolic enzymes that break down used cannabinoids to optimize their performance. Monoacylglycerol lipase (MAGL) breaks down 2-Arachidonoylglycerol (2-AG) while the Fatty Acid Amide Hydrolase (FAAH) breaks down anandamide receptors. Unlike hormones and neurotransmitters stored in the body, the ECS has to break down the Endocannabinoids after use.
How Does CBD Work with Your ECS?
CBD is a chemical compound available in the cannabis plant. There are various CBD oil-based products that many of us believe can treat various ailments. However, the relation between the Endocannabinoid System and CBD is not clear to many, mostly how it works with the ECS. CBD interacts with the ECS by binding to the CB2 and CB1 receptors to enjoy CBD Health Benefits. Also, CBD interacts with the Human Endocannabinoid System by activating multiple pathways together. CBD vs. THC relationship benefits our body as all of them aim to maintain Homeostasis Endocannabinoid System. CBD can curb the side effects of tetrahydrocannabinol, thus minimizing the psychoactive effects associated with THC.
How Was the Endocannabinoid System Discovered?
Endocannabinoid was never a common topic of study in our institutions. It was common to find our scientific books containing the cardiovascular system and the respiratory system. The main reason is that the endocannabinoid was unknown to many scientists at that time. Until 1964, Dr. Raphael Mechoulam, an Israeli scientist, identified and isolated Tetrahydrocannabinol (THC) from the cannabis plant. The discovery paved the way, and many scientists wondered how and why cannabis impacted the human body.
Allyn Howlett and William Devane later in 1988 made a breakthrough and found the first cannabinoid receptor on a rat’s brain. After mapping out the brain receptors, they found out several receptors more than the neurotransmitters. That is how they discovered the Endocannabinoid System and named it after the cannabis plant since it aided in uncovering this system.
The Endocannabinoid System’s Role in Maintaining Homeostasis
Human Endocannabinoid System influence several biological processes in the body. Homeostasis Endocannabinoid System maintains balance by managing pain, immune response, mood, energy regulation, memory, and appetite. The ECS maintains Homeostasis through the utilization of endocannabinoids and cannabinoid receptors in the body. Detection of imbalance in the body initiates cannabinoid synthesis, which interacts with the cannabinoid receptors, thus stimulating chemical response.
The process retore the Homeostasis; therefore, you can regain a normal health condition. So, cannabinoids are ideal for communication and coordination between cell types. In most cases, the body synthesizes typically enough cannabinoids required to maintain Homeostasis. However, due to some underlying health conditions, the body often does not produce enough endocannabinoids. In such cases, one is likely to suffer from an endocannabinoid deficiency. Therefore, taking phytocannabinoid supplements such as CBD edibles, topicals, and oils can encourage the body to produce cannabinoids.
Your Body and the Endocannabinoid System
The human body is like that smart machine that shut down when the smarty device paired with it is out of range. The body activates the Human Endocannabinoid system only when there is a need. When there is a hormonal imbalance, the ECS will restore balance without affecting other body functions.
ECS activation makes it to produce endocannabinoid, which reacts with the cannabinoid receptor. The body will then send an enzyme to breaks it so that it does not affect other functions. Because CBD can activate the Endocannabinoid system, they are the targeted option for restoring Homeostasis.
Initially, scientists had only discovered the presence of cannabinoids receptors in the nerves and brains. Modern scientists also find that they spread on other body parts, including skin, bone, and organs. Therefore, Endocannabinoids are the most universals & multifaceted signaling molecules. There is still currently ongoing research to understand the biological process undertaken by the human endocannabinoid system.
What Are the Health Benefits of CBD?
There have been many claims about CBD Health Benefits, but not many have been proven. According to the CBD manufacturers, they claim that CBD can relieve pain, anxiety, inflammation, depression, and insomnia. However, only one drug containing CBD has FDA approved as a treatment option for Epilepsy. It is common to find CBD products such as edibles, topicals, vapors, and oils in which all of them claim to improve your well-being.
Many of the clinical trials that have been conducted on CBD Health Benefits combine marijuana or both THC and CBD. Thus, it is never sure where phytocannabinoid helps to maintain Homeostasis in the Endocannabinoid System. The only case that has been proven beyond doubt is a research on the effect of CBD on Dravet syndrome and Lennox-Gastaut syndrome (LGS). Epidiolex can treat these two forms of Epilepsy can be treated with, which is a drug containing CBD.
Over 200 cannabinoids are available in cannabis, and THC and CBD are the abundant cannabinoids in cannabis. THC causes psychoactive feelings while CBD does not, which means they do not have dependent or abuse potential. Initially, cannabis has been a restricted drug. That is why many types of research could cover CBD. However, when the FDA eased CBD regulations in 2015, hemp farms have increased, and many industries have invested in manufacturing CBD products.
Also, scientists have invested their time and resources into uncovering the mysteries behind Cannabidiol (CBD). Although CBD has only been approved for Dravet syndrome and Lennox-Gastaut syndrome, anecdotal evidence indicates that it can treat the following conditions. Acne, arthritis pain, inflammatory pain, nausea & vomiting, sleep disorders, anxiety, depression, muscle-spasticity (in multiple sclerosis), and nerve-related pain.
How Does THC Interact with The Endocannabinoid System?
The cannabinoid produced by the cannabis plant is called phytocannabinoid, and CBD and THC are common. The molecular structures of phytocannabinoid are similar to cannabinoids produced by the body. Tetrahydrocannabinol and Anandamide have a smiler shape; thus, THC can affect various human endocannabinoid functions performed by Anandamide. This is because THC can bind to CB1 and CB2 and activate them.
There is various cannabis strain rich in THC even though it is the compound that causes psychoactive effects. When THC binds to the central nervous system CB1 receptors, it reduces dopamine and affects other physiological changes. Moreover, THC can also bind with the CB2 receptors as a partial agonist. Scientists have produced synthetic THC that’s more effective, but THC’s impact is not desirable.
The Bottom Line
The human endocannabinoid system plays a significant role in the maintenance of Homeostasis. It’s a network of cannabinoids, enzymes, hormones, and endocannabinoid receptors that restore balance in the body. When the body doesn’t produce enough cannabinoids, pain, inflammation, depression, change in appetite, and weight, one may face health conditions. Therefore, having a clear understanding of how ECS work helps you appreciate CBD’s role in our body. The ECS discovery led to a rise in the CBD industry as scientists clearly understood how cannabinol could positively impact the ECS, thus improving general health.